Results
| PMID | 18206876 |
| Gene Name | HSPA6 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 66 |
| Population details | 66 (45 women had laparoscopically and histologically confirmed endometriosis, 21 women did not have endometriosis) |
| Sex | Female |
| Associated genes | HSP70b |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2009 Jan;91(1):46-50. doi: 10.1016/j.fertnstert.2007.11.021. Epub Lambrinoudaki, Irene V| Augoulea, Areti| Christodoulakos, George E| Economou, Emmanuel V| Kaparos, George| Kontoravdis, Antonios| Papadias, Constantinos| Creatsas, George Second Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital, Athens, Greece. ilambrinoudaki@hotmail.com OBJECTIVE: To evaluate the hypothesis of increased systemic oxidative stress in patients with endometriosis. SETTING: Tertiary care university hospital. DESIGN: Cross-sectional study. PATIENT(S): Sixty-six women of reproductive age undergoing laparoscopy. INTERVENTION(S): All women were investigated for endometriotic foci during laparoscopy. Forty-five women had laparoscopically and histologically confirmed endometriosis, and 21 women did not have endometriosis. MAIN OUTCOME MEASURE(S): Four markers of oxidative stress were assessed in the serum of each patient: heat shock protein 70 (HSP70), HSP70b', thioredoxin (TRX), and ischemia-modified albumin (IMA). RESULT(S): Mean serum HSP 70b' level was higher in patients with endometriosis compared with controls (0.178 ng/mL, SD 0.103, and 0.135 ng/mL, SD 0.014, respectively). The disease stage did not affect HSP70b' levels. Heat shock protein 70, IMA, and TRX levels did not differ between patients with endometriosis and controls. Women with a history of arterial hypertension had higher mean IMA levels compared with women with normal blood pressure independently of the presence of endometriosis (106.7 [SD 25.4] U/mL and 85.0 [SD 11.5] U/mL, respectively). CONCLUSION(S): Endometriosis is associated with increased systemic oxidative stress. The implication of increased systemic oxidative stress in disease progression or the association with other oxidative stress-related pathologic conditions needs to be addressed in further studies. Mesh Terms: Adult| Biomarkers/*blood| Endometriosis/*blood/*diagnosis/surgery| Female| HSP70 Heat-Shock Proteins/*blood| Humans| Laparoscopy| Menstrual Cycle/physiology| *Oxidative Stress| Parity| Pregnancy| Reference Values| Serum Albumin/*metabolism| T |
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